PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence

CDK4/6 inhibitors are being used to treat a variety of human malignancies. In well-differentiated and dedifferentiated liposarcoma their clinical promise is associated with their ability to downregulate the MDM2 protein. The downregulation of MDM2 following treatment with CDK4/6 inhibitors also indu...

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Vydáno v:Oncogene
Hlavní autoři: Klein, Mary E., Dickson, Mark A., Antonescu, Cristina, Qin, Li-Xuan, Dooley, Scott J., Barlas, Afsar, Manova, Katia, Schwartz, Gary K., Crago, Aimee M., Singer, Samuel, Koff, Andrew, Tap, William D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137027/
https://ncbi.nlm.nih.gov/pubmed/29789718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0332-y
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