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Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors.

Senescence is an irreversible form of growth arrest and is generally considered a favorable outcome of cancer therapies, yet little is known about the molecular events that distinguish this state from readily reversible growth arrest (i.e. quiescence). Recently, we discovered that during therapy ind...

詳細記述

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書誌詳細
出版年:Mol Cell Oncol
主要な著者: Kovatcheva, Marta, Klein, Mary E., Tap, William D., Koff, Andrew
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791849/
https://ncbi.nlm.nih.gov/pubmed/29404388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1384882
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