ATRX is a regulator of therapy induced senescence in human cells

Senescence is a state of stable cell cycle exit with important implications for development and disease. Here, we demonstrate that the chromatin remodeling enzyme ATRX is required for therapy-induced senescence. ATRX accumulates in nuclear foci and is required for therapy-induced senescence in multi...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Kovatcheva, Marta, Liao, Will, Klein, Mary E., Robine, Nicolas, Geiger, Heather, Crago, Aimee M., Dickson, Mark A., Tap, William D., Singer, Samuel, Koff, Andrew
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577318/
https://ncbi.nlm.nih.gov/pubmed/28855512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00540-5
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