DNA Sequence Context Controls the Binding and Processivity of the T7 DNA Primase

Primases are key enzymes involved in DNA replication. They act on single-stranded DNA and catalyze the synthesis of short RNA primers used by DNA polymerases. Here, we investigate the DNA binding and activity of the bacteriophage T7 primase using a new workflow called high-throughput primase profili...

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Bibliographic Details
Published in:iScience
Main Authors: Afek, Ariel, Ilic, Stefan, Horton, John, Lukatsky, David B., Gordan, Raluca, Akabayov, Barak
Format: Artigo
Language:Inglês
Published: Elsevier 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136900/
https://ncbi.nlm.nih.gov/pubmed/30428370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.03.019
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