Estrogen Regulation of GRK2 Inactivates Kappa Opioid Receptor Signaling Mediating Analgesia, But Not Aversion

Activation of κ opioid receptors (KORs) produces analgesia and aversion via distinct intracellular signaling pathways, but whether G protein-biased KOR agonists can be designed to have clinical utility will depend on a better understanding of the signaling mechanisms involved. We found that KOR acti...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Abraham, Antony D., Schattauer, Selena S., Reichard, Kathryn L., Cohen, Joshua H., Fontaine, Harrison M., Song, Allisa J., Johnson, Salina D., Land, Benjamin B., Chavkin, Charles
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2018
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136151/
https://ncbi.nlm.nih.gov/pubmed/30076211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0653-18.2018
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki