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Regulation of Kappa Opioid Receptor Inactivation Depends on Sex and Cellular Site of Antagonist Action

The prototypical member of the receptor-inactivating kappa opioid receptor (KOR) antagonists, norbinaltorphimine (norBNI), produces prolonged receptor inactivation by a cJun kinase mechanism. These antagonists have potential therapeutic utility in the treatment of stress disorders; however, addition...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Reichard, Kathryn L., Newton, Keionna A., Rivera, Zeena M.G., Sotero de Menezes, Paulo M., Schattauer, Selena S., Land, Benjamin B., Chavkin, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7569314/
https://ncbi.nlm.nih.gov/pubmed/32913138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.120.000124
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