Azurin interaction with the lipid raft components ganglioside GM-1 and caveolin-1 increases membrane fluidity and sensitivity to anti-cancer drugs

Membrane lipid rafts are highly ordered microdomains and essential components of plasma membranes. In this work, we demonstrate that azurin uptake by cancer cells is, in part, mediated by caveolin-1 and GM-1, lipid rafts’ markers. This recognition is mediated by a surface exposed hydrophobic core di...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Bernardes, Nuno, Garizo, Ana Rita, Pinto, Sandra N., Caniço, Bernardo, Perdigão, Catarina, Fernandes, Fábio, Fialho, Arsenio M.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133334/
https://ncbi.nlm.nih.gov/pubmed/29963969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1489178
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