Azurin interaction with the lipid raft components ganglioside GM-1 and caveolin-1 increases membrane fluidity and sensitivity to anti-cancer drugs

Membrane lipid rafts are highly ordered microdomains and essential components of plasma membranes. In this work, we demonstrate that azurin uptake by cancer cells is, in part, mediated by caveolin-1 and GM-1, lipid rafts’ markers. This recognition is mediated by a surface exposed hydrophobic core di...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Bernardes, Nuno, Garizo, Ana Rita, Pinto, Sandra N., Caniço, Bernardo, Perdigão, Catarina, Fernandes, Fábio, Fialho, Arsenio M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133334/
https://ncbi.nlm.nih.gov/pubmed/29963969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1489178
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