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The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks

The Ataxia-telangiectasia mutated (ATM) kinase and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) are activated by DNA double-strand breaks (DSBs). These DSBs occur in the context of chromatin but how chromatin influences the activation of these kinases is not known. Here we show that...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Cycle
Prif Awduron: Huang, Ting-Hsiang, Shen, Zih-Jie, Sleckman, Barry P., Tyler, Jessica K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132960/
https://ncbi.nlm.nih.gov/pubmed/29954236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1486165
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