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Histone chaperones ASF1 and CAF-1 promote MMS22L-TONSL-mediated Rad51 loading onto ssDNA during homologous recombination in human cells
The access-repair-restore model for the role of chromatin in DNA repair infers that chromatin is a mere obstacle to DNA repair. However, here we show that blocking chromatin assembly, via knockdown of the histone chaperones ASF1A, CAF-1 or a mutation that prevents ASF1A binding to histones, hinders...
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| Опубликовано в: : | Mol Cell |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5843376/ https://ncbi.nlm.nih.gov/pubmed/29478807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.031 |
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