The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks

The Ataxia-telangiectasia mutated (ATM) kinase and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) are activated by DNA double-strand breaks (DSBs). These DSBs occur in the context of chromatin but how chromatin influences the activation of these kinases is not known. Here we show that...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Huang, Ting-Hsiang, Shen, Zih-Jie, Sleckman, Barry P., Tyler, Jessica K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132960/
https://ncbi.nlm.nih.gov/pubmed/29954236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1486165
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