Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes α-Cleavage of PrP(C)

Prion diseases are infectious and fatal neurodegenerative diseases affecting humans and animals. Transmission is possible within and between species with zoonotic potential. Currently, no prophylaxis or treatment exists. Prions are composed of the misfolded isoform PrP(Sc) of the cellular prion prot...

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Bibliographic Details
Published in:Mol Neurobiol
Main Authors: Corda, Erica, Du, Xiaotang, Shim, Su Yeon, Klein, Antonia N., Siltberg-Liberles, Jessica, Gilch, Sabine
Format: Artigo
Language:Inglês
Published: Springer US 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132731/
https://ncbi.nlm.nih.gov/pubmed/29460268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-0944-9
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