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Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes α-Cleavage of PrP(C)

Prion diseases are infectious and fatal neurodegenerative diseases affecting humans and animals. Transmission is possible within and between species with zoonotic potential. Currently, no prophylaxis or treatment exists. Prions are composed of the misfolded isoform PrP(Sc) of the cellular prion prot...

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Dades bibliogràfiques
Publicat a:Mol Neurobiol
Autors principals: Corda, Erica, Du, Xiaotang, Shim, Su Yeon, Klein, Antonia N., Siltberg-Liberles, Jessica, Gilch, Sabine
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132731/
https://ncbi.nlm.nih.gov/pubmed/29460268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-0944-9
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