Chargement en cours...
PrP overdrive: Does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease?
Knockout of the cellular prion protein (PrP(C)) in mice is tolerated, as is complete elimination of the protein’s N-terminal domain. However, deletion of select short segments between the N- and C-terminal domains is lethal. How can one reconcile this apparent paradox? Research over the last few yea...
Enregistré dans:
| Auteurs principaux: | , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Landes Bioscience
2014
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4189888/ https://ncbi.nlm.nih.gov/pubmed/24721836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.28796 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|