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PrP overdrive: Does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease?
Knockout of the cellular prion protein (PrP(C)) in mice is tolerated, as is complete elimination of the protein’s N-terminal domain. However, deletion of select short segments between the N- and C-terminal domains is lethal. How can one reconcile this apparent paradox? Research over the last few yea...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , |
|---|---|
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Landes Bioscience
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4189888/ https://ncbi.nlm.nih.gov/pubmed/24721836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.28796 |
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