Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling

Elevations of liver enzymes have been observed in clinical trials with BAL30072, a novel antibiotic. In vitro assays have identified potential mechanisms for the observed hepatotoxicity, including electron transport chain (ETC) inhibition and reactive oxygen species (ROS) generation. DILIsym, a quan...

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Publicat a:Clin Transl Sci
Autors principals: Woodhead, Jeffrey L., Paech, Franziska, Maurer, Martina, Engelhardt, Marc, Schmitt‐Hoffmann, Anne H., Spickermann, Jochen, Messner, Simon, Wind, Mathias, Witschi, Anne‐Therese, Krähenbühl, Stephan, Siler, Scott Q., Watkins, Paul B., Howell, Brett A.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132362/
https://ncbi.nlm.nih.gov/pubmed/29877622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12560
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