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Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

Tyrosine kinase inhibitors (TKIs) are anticancer drugs with a lesser toxicity than classical chemotherapeutic agents but still with a narrow therapeutic window. While hepatotoxicity is known for most TKIs, underlying mechanisms remain mostly unclear. We therefore aimed at investigating mechanisms of...

詳細記述

保存先:
書誌詳細
出版年:Front Pharmacol
主要な著者: Paech, Franziska, Bouitbir, Jamal, Krähenbühl, Stephan
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469902/
https://ncbi.nlm.nih.gov/pubmed/28659801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00367
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