Загрузка...

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

Tyrosine kinase inhibitors (TKIs) are anticancer drugs with a lesser toxicity than classical chemotherapeutic agents but still with a narrow therapeutic window. While hepatotoxicity is known for most TKIs, underlying mechanisms remain mostly unclear. We therefore aimed at investigating mechanisms of...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Front Pharmacol
Главные авторы: Paech, Franziska, Bouitbir, Jamal, Krähenbühl, Stephan
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469902/
https://ncbi.nlm.nih.gov/pubmed/28659801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00367
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!