Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

por Paech, Franziska, Bouitbir, Jamal, Krähenbühl, Stephan
Publicado no Front Pharmacol (2017)

Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells

por Sanvee, Gerda M., Bouitbir, Jamal, Krähenbühl, Stephan
Publicado no Sci Rep (2019)

Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells

por Roos, Noëmi Johanna, Aliu, Diell, Bouitbir, Jamal, Krähenbühl, Stephan
Publicado no Front Pharmacol (2020)

Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle Expression

por Panajatovic, Miljenko Valentin, Singh, François, Krähenbühl, Stephan, Bouitbir, Jamal
Publicado no Biomedicines (2020)

Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression

por Panajatovic, Miljenko V., Singh, Francois, Krähenbühl, Stephan, Bouitbir, Jamal
Publicado no Int J Mol Sci (2021)

Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient

por Bühler, Tim, Medinger, Michael, Bouitbir, Jamal, Krähenbühl, Stephan, Leuppi-Taegtmeyer, Anne
Publicado no Front Pharmacol (2019)

Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis

por Rudin, Deborah, Schmutz, Maurice, Roos, Noëmi Johanna, Bouitbir, Jamal, Krähenbühl, Stephan
Publicado no Biomedicines (2020)

Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples

por Gómez, Cristina, Stücheli, Simon, Kratschmar, Denise V., Bouitbir, Jamal, Odermatt, Alex
Publicado no Metabolites (2020)

Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice

por Haegler, Patrizia, Grünig, David, Berger, Benjamin, Terracciano, Luigi, Krähenbühl, Stephan, Bouitbir, Jamal
Publicado no PLoS One (2017)

Exogenous Iron Increases Fasciocidal Activity and Hepatocellular Toxicity of the Synthetic Endoperoxides OZ78 and MT04

por Brecht, Karin, Kirchhofer, Carla, Bouitbir, Jamal, Trapani, Francesca, Keiser, Jennifer, Krähenbühl, Stephan
Publicado no Int J Mol Sci (2019)

Para-Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells

por Zhou, Xun, Bouitbir, Jamal, Liechti, Matthias E., Krähenbühl, Stephan, Mancuso, Riccardo V.
Publicado no Int J Mol Sci (2020)

Hyperthermia Increases Neurotoxicity Associated with Novel Methcathinones

por Zhou, Xun, Bouitbir, Jamal, Liechti, Matthias E., Krähenbühl, Stephan, Mancuso, Riccardo V.
Publicado no Cells (2020)

Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells

por Bouitbir, Jamal, Panajatovic, Miljenko Valentin, Frechard, Theo, Roos, Noëmi Johanna, Krähenbühl, Stephan
Publicado no Front Pharmacol (2020)

Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency

por Bouitbir, Jamal, Haegler, Patrizia, Singh, François, Joerin, Lorenz, Felser, Andrea, Duthaler, Urs, Krähenbühl, Stephan
Publicado no Front Physiol (2016)

Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts

por Zhou, Xun, Luethi, Dino, Sanvee, Gerda M., Bouitbir, Jamal, Liechti, Matthias E., Krähenbühl, Stephan
Publicado no Int J Mol Sci (2019)

PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice

por Panajatovic, Miljenko Valentin, Singh, François, Roos, Noëmi Johanna, Duthaler, Urs, Handschin, Christoph, Krähenbühl, Stephan, Bouitbir, Jamal
Publicado no Acta Physiol (Oxf) (2019)

Apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection

por Zoll, Joffrey, Bouitbir, Jamal, Sirvent, Pascal, Klein, Alexis, Charton, Antoine, Jimenez, Liliana, Péronnet, François R, Geny, Bernard, Richard, Ruddy
Publicado no Drug Des Devel Ther (2015)

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

por Bouitbir, Jamal, Charles, Anne-Laure, Echaniz-Laguna, Andoni, Kindo, Michel, Daussin, Frédéric, Auwerx, Johan, Piquard, François, Geny, Bernard, Zoll, Joffrey
Publicado em 2012

Left Ventricular Transmural Gradient in Mitochondrial Respiration Is Associated with Increased Sub-Endocardium Nitric Oxide and Reactive Oxygen Species Productions

por Kindo, Michel, Gerelli, Sébastien, Bouitbir, Jamal, Hoang Minh, Tam, Charles, Anne-Laure, Mazzucotelli, Jean-Philippe, Zoll, Joffrey, Piquard, François, Geny, Bernard
Publicado no Front Physiol (2016)

Pressure overload-induced mild cardiac hypertrophy reduces left ventricular transmural differences in mitochondrial respiratory chain activity and increases oxidative stress

por Kindo, Michel, Gerelli, Sébastien, Bouitbir, Jamal, Charles, Anne-Laure, Zoll, Joffrey, Hoang Minh, Tam, Monassier, Laurent, Favret, Fabrice, Piquard, François, Geny, Bernard
Publicado em 2012