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PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice
AIM: Statins decrease cardiovascular complications, but can induce myopathy. Here, we explored the implication of PGC-1α in statin-associated myotoxicity. METHODS: We treated PGC-1α knockout (KO), PGC-1α over-expression (OE) and wild-type mice (WT) mice orally with 5 mg simvastatin kg(-1) day(-1) fo...
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| Publicado no: | Acta Physiol (Oxf) |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7100017/ https://ncbi.nlm.nih.gov/pubmed/31605661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/APHA.13402 |
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