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PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice

AIM: Statins decrease cardiovascular complications, but can induce myopathy. Here, we explored the implication of PGC-1α in statin-associated myotoxicity. METHODS: We treated PGC-1α knockout (KO), PGC-1α over-expression (OE) and wild-type mice (WT) mice orally with 5 mg simvastatin kg(-1) day(-1) fo...

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書誌詳細
出版年:Acta Physiol (Oxf)
主要な著者: Panajatovic, Miljenko Valentin, Singh, François, Roos, Noëmi Johanna, Duthaler, Urs, Handschin, Christoph, Krähenbühl, Stephan, Bouitbir, Jamal
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7100017/
https://ncbi.nlm.nih.gov/pubmed/31605661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/APHA.13402
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