Population Pharmacokinetic Modelling of Ceftazidime and Avibactam in the Plasma and Epithelial Lining Fluid of Healthy Volunteers

OBJECTIVES: Our objective was to develop population pharmacokinetic (PK) models for ceftazidime and avibactam in the plasma and epithelial lining fluid (ELF) of healthy volunteers and to compare ELF concentrations to plasma PK/pharmacodynamic (PD) targets. METHODS: Plasma and ELF population PK model...

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Vydáno v:Drugs R D
Hlavní autoři: Dimelow, Richard, Wright, James G., MacPherson, Merran, Newell, Paul, Das, Shampa
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2018
Témata:
Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131119/
https://ncbi.nlm.nih.gov/pubmed/30054895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40268-018-0241-0
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