Pharmacokinetics and Penetration of Ceftazidime and Avibactam into Epithelial Lining Fluid in Thigh- and Lung-Infected Mice

Ceftazidime and the β-lactamase inhibitor avibactam constitute a new, potentially highly active combination in the battle against extended-spectrum-β-lactamase (ESBL)-producing bacteria. To determine possible clinical use, it is important to know the pharmacokinetic profiles of the compounds related...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Berkhout, Johanna, Melchers, Maria J., van Mil, Anita C., Seyedmousavi, Seyedmojtaba, Lagarde, Claudia M., Nichols, Wright W., Mouton, Johan W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356781/
https://ncbi.nlm.nih.gov/pubmed/25645843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04627-14
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