Ceftazidime‐Avibactam Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Across Adult Indications and Patient Subgroups

Ceftazidime‐avibactam is a novel β‐lactam/β‐lactamase inhibitor combination for the treatment of serious infections caused by resistant gram‐negative pathogens. Population pharmacokinetic (PopPK) models were built to incorporate pharmacokinetic (PK) data from five phase III trials in patients with c...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Transl Sci
Hauptverfasser: Li, Jianguo, Lovern, Mark, Green, Michelle L., Chiu, Joannellyn, Zhou, Diansong, Comisar, Craig, Xiong, Yuan, Hing, Jeremy, MacPherson, Merran, Wright, James G., Riccobene, Todd, Carrothers, Timothy J., Das, Shampa
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440567/
https://ncbi.nlm.nih.gov/pubmed/30221827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12585
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