PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2

PHR (PAM/Highwire/RPM-1) proteins are conserved RING E3 ubiquitin ligases that function in developmental processes, such as axon termination and synapse formation, as well as axon degeneration. At present, our understanding of how PHR proteins form ubiquitin ligase complexes remains incomplete. Alth...

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Vydáno v:J Biol Chem
Hlavní autoři: Desbois, Muriel, Crawley, Oliver, Evans, Paul R., Baker, Scott T., Masuho, Ikuo, Yasuda, Ryohei, Grill, Brock
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130950/
https://ncbi.nlm.nih.gov/pubmed/29997255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002176
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