PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2

PHR (PAM/Highwire/RPM-1) proteins are conserved RING E3 ubiquitin ligases that function in developmental processes, such as axon termination and synapse formation, as well as axon degeneration. At present, our understanding of how PHR proteins form ubiquitin ligase complexes remains incomplete. Alth...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Desbois, Muriel, Crawley, Oliver, Evans, Paul R., Baker, Scott T., Masuho, Ikuo, Yasuda, Ryohei, Grill, Brock
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130950/
https://ncbi.nlm.nih.gov/pubmed/29997255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002176
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