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An atypical SCF-like ubiquitin ligase complex promotes Wallerian degeneration through regulation of axonal Nmnat2

Axon degeneration is a tightly regulated self-destructive program that is a critical feature of many neurodegenerative diseases, but the molecular mechanisms regulating this program remain poorly understood. Here we identify Skp1a, a core component of an SCF-type E3 ubiquitin ligase complex, as a cr...

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Publicado en:Cell Rep
Autores principales: Yamagishi, Yuya, Tessier-Lavigne, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075525/
https://ncbi.nlm.nih.gov/pubmed/27732853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.043
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