The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

Axonal degeneration is a hallmark of many neuropathies, neurodegenerative diseases, and injuries. Here, using a Drosophila injury model, we have identified a highly conserved E3 ubiquitin ligase, Highwire (Hiw), as an important regulator of axonal and synaptic degeneration. Mutations in hiw strongly...

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Detalhes bibliográficos
Main Authors: Xiong, Xin, Hao, Yan, Sun, Kan, Li, Jiaxing, Li, Xia, Mishra, Bibhudatta, Soppina, Pushpanjali, Wu, Chunlai, Hume, Richard I., Collins, Catherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514318/
https://ncbi.nlm.nih.gov/pubmed/23226106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001440
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