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The effect of truncation on prion-like properties of α-synuclein

Increasing evidence suggests that α-synuclein (αS) aggregates in brains of individuals with Parkinson's disease and dementia with Lewy bodies can spread in a prion-like manner. Although the initial αS nuclei are pivotal in determining αS fibril polymorphs and resulting phenotypes, it is not cle...

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Vydáno v:J Biol Chem
Hlavní autoři: Terada, Makoto, Suzuki, Genjiro, Nonaka, Takashi, Kametani, Fuyuki, Tamaoka, Akira, Hasegawa, Masato
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130941/
https://ncbi.nlm.nih.gov/pubmed/30030380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001862
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