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Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions
α-Synuclein (αsyn) aggregates into toxic fibrils in multiple neurodegenerative diseases where these fibrils form characteristic pathological inclusions such as Lewy bodies (LBs). The mechanisms initiating αsyn aggregation into fibrils are unclear, but ubiquitous post-translational modifications of α...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6295729/ https://ncbi.nlm.nih.gov/pubmed/30327435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005603 |
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