Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators

Transcriptional coactivators are a molecular recognition marvel because a single domain within these proteins, the activator binding domain or ABD, interacts with multiple compositionally diverse transcriptional activators. Also remarkable is the structural diversity among ABDs, which range from con...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Henderson, Andrew R., Henley, Matthew J., Foster, Nicholas J., Peiffer, Amanda L., Beyersdorf, Matthew S., Stanford, Kevon D., Sturlis, Steven M., Linhares, Brian M., Hill, Zachary B., Wells, James A., Cierpicki, Tomasz, Brooks, Charles L., Fierke, Carol A., Mapp, Anna K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130367/
https://ncbi.nlm.nih.gov/pubmed/30127017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806202115
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