Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators

Transcriptional coactivators are a molecular recognition marvel because a single domain within these proteins, the activator binding domain or ABD, interacts with multiple compositionally diverse transcriptional activators. Also remarkable is the structural diversity among ABDs, which range from con...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Henderson, Andrew R., Henley, Matthew J., Foster, Nicholas J., Peiffer, Amanda L., Beyersdorf, Matthew S., Stanford, Kevon D., Sturlis, Steven M., Linhares, Brian M., Hill, Zachary B., Wells, James A., Cierpicki, Tomasz, Brooks, Charles L., Fierke, Carol A., Mapp, Anna K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130367/
https://ncbi.nlm.nih.gov/pubmed/30127017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806202115
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