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Prepaying the entropic cost for allosteric regulation in KIX
The kinase-inducible domain interacting (KIX) domain of the CREB binding protein (CBP) is capable of simultaneously binding two intrinsically disordered transcription factors, such as the mixed-lineage leukemia (MLL) and c-Myb peptides, at isolated interaction sites. In vitro, the affinity for bindi...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4143015/ https://ncbi.nlm.nih.gov/pubmed/25002472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405831111 |
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