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Prepaying the entropic cost for allosteric regulation in KIX

The kinase-inducible domain interacting (KIX) domain of the CREB binding protein (CBP) is capable of simultaneously binding two intrinsically disordered transcription factors, such as the mixed-lineage leukemia (MLL) and c-Myb peptides, at isolated interaction sites. In vitro, the affinity for bindi...

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Bibliografiske detaljer
Main Authors: Law, Sean M., Gagnon, Jessica K., Mapp, Anna K., Brooks, Charles L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143015/
https://ncbi.nlm.nih.gov/pubmed/25002472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405831111
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