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Collision Induced Unfolding Reveals Unique Fingerprints for Remote Protein Interaction Sites in the KIX Regulation Domain
The kinase-inducible domain (KIX) of the transcriptional coactivator CBP binds multiple transcriptional regulators through two allosterically-connected sites. Establishing a method for observing activator-specific KIX conformations would facilitate the discovery of drug-like molecules that capture s...
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| Publicado no: | J Am Soc Mass Spectrom |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6320266/ https://ncbi.nlm.nih.gov/pubmed/30136215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-018-2043-6 |
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