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Collision Induced Unfolding Differentiates Functional Variants of the KCNQ1 Voltage Sensor Domain
The KCNQ1 voltage-gated potassium channel regulates the repolarization of cardiac cells and a plurality of point mutations in its voltage sensing domain (VSD) are associated with toxic gain or loss of pore function resulting in disease. As is the case with many disease-associated membrane proteins,...
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| Publicado no: | J Am Soc Mass Spectrom |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8106873/ https://ncbi.nlm.nih.gov/pubmed/32960579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jasms.0c00288 |
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