Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease

MicroRNAs (miRs) posttranscriptionally regulate mRNA and its translation into protein, and are considered master controllers of genes modulating normal physiology and disease. There is growing interest in how miRs change with drug treatment, and leveraging this for precision guided therapy. Here we...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Kokkonen-Simon, Kristen M., Saberi, Amir, Nakamura, Taishi, Ranek, Mark J., Zhu, Guangshuo, Bedja, Djahida, Kuhn, Michaela, Halushka, Marc K., Lee, Dong Ik, Kass, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129132/
https://ncbi.nlm.nih.gov/pubmed/30089721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121739
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