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Prevention of Protein Kinase G-1α Oxidation Suppresses Anti-Hypertrophic/Anti-fibrotic Effects from PDE5 Inhibition but not sGC Stimulation
BACKGROUND: Stimulation of soluble guanylate cyclase (sGC) or inhibition of phosphodiesterase type-5 (PDE5) activates protein kinase G-1α (PKG1α) to counteract cardiac hypertrophy and failure. PKG1α acts within localized intracellular domains; however, its oxidation at cysteine-42, linking homo-mono...
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| Publicado no: | Circ Heart Fail |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5858464/ https://ncbi.nlm.nih.gov/pubmed/29545395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004740 |
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