Pressure-Overload Magnitude-Dependence of the Anti-Hypertrophic Efficacy of PDE5A Inhibition

Increased myocardial cGMP, achieved by enhancing cyclase activity or impeding cGMP hydrolysis by phosphodiesterase type-5 (PDE5A), suppresses cellular and whole organ hypertrophy. The efficacy of the latter also requires cyclase stimulation and may depend upon co-activation of maladaptive signaling...

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Bibliografiske detaljer
Main Authors: Nagayama, Takahiro, Hsu, Steven, Zhang, Manling, Koitabashi, Norimichi, Bedja, Djahida, Gabrielson, Kathleen L., Takimoto, Eiki, Kass, David A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703675/
https://ncbi.nlm.nih.gov/pubmed/19159628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2008.12.008
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