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Pressure-Overload Magnitude-Dependence of the Anti-Hypertrophic Efficacy of PDE5A Inhibition
Increased myocardial cGMP, achieved by enhancing cyclase activity or impeding cGMP hydrolysis by phosphodiesterase type-5 (PDE5A), suppresses cellular and whole organ hypertrophy. The efficacy of the latter also requires cyclase stimulation and may depend upon co-activation of maladaptive signaling...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2703675/ https://ncbi.nlm.nih.gov/pubmed/19159628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2008.12.008 |
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