Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice

The heart initially compensates for hypertension-mediated pressure overload by enhancing its contractile force and developing hypertrophy without dilation. G(q) protein–coupled receptor pathways become activated and can depress function, leading to cardiac failure. Initial adaptation mechanisms to r...

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Detalhes bibliográficos
Main Authors: Takimoto, Eiki, Koitabashi, Norimichi, Hsu, Steven, Ketner, Elizabeth A., Zhang, Manling, Nagayama, Takahiro, Bedja, Djahida, Gabrielson, Kathleen L., Blanton, Robert, Siderovski, David P., Mendelsohn, Michael E., Kass, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631292/
https://ncbi.nlm.nih.gov/pubmed/19127022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35620
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