Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice

The heart initially compensates for hypertension-mediated pressure overload by enhancing its contractile force and developing hypertrophy without dilation. G(q) protein–coupled receptor pathways become activated and can depress function, leading to cardiac failure. Initial adaptation mechanisms to r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Takimoto, Eiki, Koitabashi, Norimichi, Hsu, Steven, Ketner, Elizabeth A., Zhang, Manling, Nagayama, Takahiro, Bedja, Djahida, Gabrielson, Kathleen L., Blanton, Robert, Siderovski, David P., Mendelsohn, Michael E., Kass, David A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2009
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631292/
https://ncbi.nlm.nih.gov/pubmed/19127022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35620
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