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Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice
The heart initially compensates for hypertension-mediated pressure overload by enhancing its contractile force and developing hypertrophy without dilation. G(q) protein–coupled receptor pathways become activated and can depress function, leading to cardiac failure. Initial adaptation mechanisms to r...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631292/ https://ncbi.nlm.nih.gov/pubmed/19127022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35620 |
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