Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice

The heart initially compensates for hypertension-mediated pressure overload by enhancing its contractile force and developing hypertrophy without dilation. G(q) protein–coupled receptor pathways become activated and can depress function, leading to cardiac failure. Initial adaptation mechanisms to r...

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Autori principali: Takimoto, Eiki, Koitabashi, Norimichi, Hsu, Steven, Ketner, Elizabeth A., Zhang, Manling, Nagayama, Takahiro, Bedja, Djahida, Gabrielson, Kathleen L., Blanton, Robert, Siderovski, David P., Mendelsohn, Michael E., Kass, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631292/
https://ncbi.nlm.nih.gov/pubmed/19127022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35620
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