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Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-existing Advanced Hypertrophy due to Pressure-Overload
OBJECTIVE: To test the efficacy of phosphodiesterase type-5 (PDE5A) inhibition for treating advanced hypertrophy/remodeling due to pressure-overload, and to elucidate cellular and molecular mechanisms for this response. BACKGROUND: Sildenafil (SIL) inhibits cyclic GMP-specific PDE5A and can blunt th...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978969/ https://ncbi.nlm.nih.gov/pubmed/19130990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2008.08.069 |
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