Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway

AIMS: Cyclic GMP (cGMP)-specific phosphodiesterase 5 (PDE5) inhibition by sildenafil (SIL) activates myocardial cGMP-dependent protein kinase G (PKG) and blunts cardiac hypertrophy. To date, the only documented target of PKG in myocardium is the serine–threonine phosphatase calcineurin (Cn), which i...

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Главные авторы: Hsu, Steven, Nagayama, Takahiro, Koitabashi, Norimichi, Zhang, Manling, Zhou, Liye, Bedja, Djahida, Gabrielson, Kathleen L., Molkentin, Jeffery D., Kass, David A., Takimoto, Eiki
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2009
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721646/
https://ncbi.nlm.nih.gov/pubmed/19029137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvn324
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