Myocardial Remodeling is Controlled by Myocyte-targeted Gene Regulation of Phosphodiesterase Type-5

OBJECTIVES: We tested the hypothesis that bi-directional, gene-targeted regulation of cardiomyocyte cGMP-selective phosphodiesterase type 5 (PDE5) influences maladaptive remodeling in hearts subjected to sustained pressure-overload. BACKGROUND: PDE5 expression is up-regulated in human hypertrophied...

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Detalhes bibliográficos
Main Authors: Zhang, Manling, Takimoto, Eiki, Hsu, Steven, Lee, Dong I., Nagayama, Takahiro, Danner, Thomas, Koitabashi, Norimichi, Barth, Andreas S., Bedja, Djahida, Gabrielson, Kathleen L, Wang, Yibin, Kass, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036840/
https://ncbi.nlm.nih.gov/pubmed/20970280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2010.08.612
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