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Myocardial Remodeling is Controlled by Myocyte-targeted Gene Regulation of Phosphodiesterase Type-5
OBJECTIVES: We tested the hypothesis that bi-directional, gene-targeted regulation of cardiomyocyte cGMP-selective phosphodiesterase type 5 (PDE5) influences maladaptive remodeling in hearts subjected to sustained pressure-overload. BACKGROUND: PDE5 expression is up-regulated in human hypertrophied...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3036840/ https://ncbi.nlm.nih.gov/pubmed/20970280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2010.08.612 |
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