HDAC11 suppresses the thermogenic program of adipose tissue via BRD2

Little is known about the biological function of histone deacetylase 11 (HDAC11), which is the lone class IV HDAC. Here, we demonstrate that deletion of HDAC11 in mice stimulates brown adipose tissue (BAT) formation and beiging of white adipose tissue (WAT). Consequently, HDAC11-deficient mice exhib...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Bagchi, Rushita A., Ferguson, Bradley S., Stratton, Matthew S., Hu, Tianjing, Cavasin, Maria A., Sun, Lei, Lin, Ying-Hsi, Liu, Dianxin, Londono, Pilar, Song, Kunhua, Pino, Maria F., Sparks, Lauren M., Smith, Steven R., Scherer, Philipp E., Collins, Sheila, Seto, Edward, McKinsey, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129125/
https://ncbi.nlm.nih.gov/pubmed/30089714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120159
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