IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks

Focal adhesion kinase (FAK) mediates tumor cell–intrinsic behaviors that promote tumor growth and metastasis. We previously showed that FAK also induces the expression of inflammatory genes that inhibit antitumor immunity in the microenvironment. Here, we identified a crucial, previously unknown rol...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Signal
Prif Awduron: Serrels, Bryan, McGivern, Niamh, Canel, Marta, Byron, Adam, Johnson, Sarah C, Mcsorley, Henry, Quinn, Niall, Taggart, David, Von Kreigsheim, Alex, Anderton, Stephen M, Serrels, Alan, Frame, Margaret C
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128400/
https://ncbi.nlm.nih.gov/pubmed/29208683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aan8355
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