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Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants

Human influenza virus rapidly accumulates mutations in its major surface protein hemagglutinin (HA). The evolutionary success of influenza virus lineages depends on how these mutations affect HA’s functionality and antigenicity. Here we experimentally measure the effects on viral growth in cell cult...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Lee, Juhye M., Huddleston, John, Doud, Michael B., Hooper, Kathryn A., Wu, Nicholas C., Bedford, Trevor, Bloom, Jesse D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126756/
https://ncbi.nlm.nih.gov/pubmed/30104379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806133115
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