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Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA.

The innate-immune restriction factor MxA inhibits influenza replication by targeting the viral nucleoprotein (NP). Human influenza virus is more resistant than avian influenza virus to inhibition by human MxA, and prior work has compared human and avian viral strains to identify amino-acid differenc...

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Detalhes bibliográficos
Main Authors: Orr Ashenberg, Jai Padmakumar, Michael B Doud, Jesse D Bloom
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2017-03-01
Colecção:PLoS Pathogens
Acesso em linha:http://europepmc.org/articles/PMC5383324?pdf=render
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