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Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants

Human influenza virus rapidly accumulates mutations in its major surface protein hemagglutinin (HA). The evolutionary success of influenza virus lineages depends on how these mutations affect HA’s functionality and antigenicity. Here we experimentally measure the effects on viral growth in cell cult...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Lee, Juhye M., Huddleston, John, Doud, Michael B., Hooper, Kathryn A., Wu, Nicholas C., Bedford, Trevor, Bloom, Jesse D.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126756/
https://ncbi.nlm.nih.gov/pubmed/30104379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806133115
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