Compensation between CSF1R(+) macrophages and Foxp3(+) Treg cells drives resistance to tumor immunotherapy

Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3(+) regulatory T (Treg) cells promote tumor progression by limiting antitumor immunity. Here we show that genetic ablation of CSF1 in color...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Gyori, David, Lim, Ee Lyn, Grant, Francis M., Spensberger, Dominik, Roychoudhuri, Rahul, Shuttleworth, Stephen J., Okkenhaug, Klaus, Stephens, Len R., Hawkins, Phillip T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124419/
https://ncbi.nlm.nih.gov/pubmed/29875321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120631
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