Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors

Multiple modes of immunosuppression restrain immune function within tumors. We previously reported that phosphoinositide 3-kinase δ (PI3Kδ) inactivation in mice confers resistance to a range of tumor models by disrupting immunosuppression mediated by regulatory T cells (Tregs). The PI3Kδ inhibitor i...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Lim, Ee Lyn, Cugliandolo, Fiorella M., Rosner, Dalya R., Gyori, David, Roychoudhuri, Rahul, Okkenhaug, Klaus
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124416/
https://ncbi.nlm.nih.gov/pubmed/29875319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120626
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