Genetic or Pharmaceutical Blockade of Phosphoinositide 3-Kinase P110δ Prevents Chronic Rejection of Heart Allografts

Chronic rejection is the major cause of long-term heart allograft failure, characterized by tissue infiltration by recipient T cells with indirect allospecificity. Phosphoinositol-3-kinase p110δ is a key mediator of T cell receptor signaling, regulating both T cell activation and migration of primed...

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Detalhes bibliográficos
Main Authors: Ying, Huijun, Fu, Hongmei, Rose, Marlene L., McCormack, Ann M., Sarathchandra, Padmini, Okkenhaug, Klaus, Marelli-Berg, Federica M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316549/
https://ncbi.nlm.nih.gov/pubmed/22479345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032892
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