Enhancing IgG distribution to lung mucosal tissue improves protective effect of anti–Pseudomonas aeruginosa antibodies

IgG antibodies are abundantly present in the vasculature but to a much lesser extent in mucosal tissues. This contrasts with antibodies of the IgA and IgM isotype that are present at high concentration in mucosal secretions due to active delivery by the polymeric Ig receptor (pIgR). IgG is the prefe...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Borrok, M. Jack, DiGiandomenico, Antonio, Beyaz, Nurten, Marchetti, Gabriela M., Barnes, Arnita S., Lekstrom, Kristen J., Phipps, Sandrina S., McCarthy, Michael P., Wu, Herren, Dall’Acqua, William F., Tsui, Ping, Gupta, Ruchi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124411/
https://ncbi.nlm.nih.gov/pubmed/29925682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97844
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