FGFR1 underlies obesity-associated progression of estrogen receptor–positive breast cancer after estrogen deprivation

Obesity increases breast cancer mortality by promoting resistance to therapy. Here, we identified regulatory pathways in estrogen receptor–positive (ER-positive) tumors that were shared between patients with obesity and those with resistance to neoadjuvant aromatase inhibition. Among these was fibro...

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Pubblicato in:JCI Insight
Autori principali: Wellberg, Elizabeth A., Kabos, Peter, Gillen, Austin E., Jacobsen, Britta M., Brechbuhl, Heather M., Johnson, Stevi J., Rudolph, Michael C., Edgerton, Susan M., Thor, Ann D., Anderson, Steven M., Elias, Anthony, Zhou, Xi Kathy, Iyengar, Neil M., Morrow, Monica, Falcone, Domenick J., El-Hely, Omar, Dannenberg, Andrew J., Sartorius, Carol A., MacLean, Paul S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124402/
https://ncbi.nlm.nih.gov/pubmed/30046001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120594
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