Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations

Obesity is associated with an increased risk of breast cancer in post-menopausal women and decreased risk in pre-menopausal women. Conversely, in BRCA1/2 mutation carriers, pre-menopausal obesity is associated with early-onset breast cancer. Here we show that obese, pre-menopausal BRCA1/2 mutation c...

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Veröffentlicht in:NPJ Breast Cancer
Hauptverfasser: Iyengar, Neil M., Zhou, Xi Kathy, Mendieta, Hillary, El-Hely, Omar, Giri, Dilip D., Winston, Lisle, Falcone, Domenick J., Wang, Hanhan, Meng, Lingsong, Ha, Taehoon, Pollak, Michael, Morrow, Monica, Dannenberg, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921427/
https://ncbi.nlm.nih.gov/pubmed/33649363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-021-00226-8
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